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Biosystems Engineering Laboratory

 
Cyanobacterial engineering

Integrating multi-omics, 13C flux analysis, and synthetic biology to engineer cyanobacteria for sustainable biomanufacturing.

Human Metabolomics

Untargeted and targeted metabolic profiling to study human metabolism and disease prognosis.

Bioprocess Technology

Metabolism-guided bioprocess optimization for therapeutic protein and enzyme production.

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​About us

 

​​The Biosystems Engineering Laboratory is a research group headed by Prof. Pramod Wangikar at IIT Bombay. We investigate the metabolic basis of biological systems to develop innovative solutions in healthcare, sustainability, and biotechnology. Our research seeks to understand how metabolism underpins cellular function and how it can be engineered or modulated to achieve specific outcomes. To explore these questions, we use advanced metabolomics, combining mass spectrometry with AI-based data analysis, computational modeling, and flux analysis to quantify and interpret metabolic activity across microbial and human systems.

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Our work spans diverse areas, including the metabolic engineering of fast-growing cyanobacteria for enhanced CO₂ capture and sustainable bioproduction, metabolomics-based biomarker discovery for prognosis of complex diseases such as diabetes and cardiovascular disorders, and bioprocess optimization using spent media analysis and dynamic modeling approach for the production of therapeutic proteins and enzymes. The lab combines strong conceptual foundations in mass spectrometry, synthetic biology, and bioprocess technology with state-of-the-art infrastructure. Supported by funding from DBT (Government of India), Praj Industries, and the Wadhwani Foundation (WRCB), our lab fosters a collaborative and interdisciplinary environment for research at the interface of biology and engineering.

Wangikar group

Clarity Bio Systems

 
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​Clarity Bio Systems is our home-grown deep-tech startup, incubated at SINE,

IIT Bombay.

Built on our research expertise, Clarity offers end-to-end metabolomics solutions, from LC-MS/GC-MS–based metabolite profiling to AI-driven data analysis and interpretation via our in-house platform, MSOne, to support applications in healthcare, sustainability, and biomanufacturing.

Clarity collaborates with academic labs, biopharma, and clinical institutions.

Recent updates

 

PhD thesis

Meghna Srivastava successfully defended her PhD thesis!

6th May 2025

View all events

New research from the lab

Banerjee et al. (2025)  DuReS: An R Package for Denoising Experimental Tandem Mass Spectra and Metabolite Annotation

30th April 2025

Metabolomics Conference

24-26th February 2025

​Address

Department of Chemical Engineering,

IIT Bombay

Contact

Lab: +91 22 25767232  

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